(* Corresponding author; § Equal contribution)

  1. Sinha S,§ Biswas A,§ Mondal J* and Mandal K* (2021) Computational and experimental studies of Plasmodium falciparum protein PfAMA1 domain-II loop dynamics: implications in PfAMA1-PfRON2 binding event. bioRxiv, doi:https://doi.org/10.1101/2021.10.10.463826.

  2. Mannuthodikayil J, Sinha S, Singh S, Biswas A, Ali I, Mashurabad PC, Tabassum W, Vydyam P, Bhattacharyya, MK and Mandal K* (2021) A chimeric peptide inhibits red blood cell invasion by Plasmodium falciparum with hundredfold increased efficacy. bioRxiv, doi:https://doi.org/10.1101/2021.09.28.462119.

  3. Das A, Yadav A, Gupta M, Purushotham R, Terse VL, Vishvakarma V, Singh S, Nandi T, Banerjee A, Mandal K, Gosavi S, Das R, Ainavarapu SRK and Maiti S (2021) Rational design of protein-specific folding modifiers. Journal of the American Chemical Society, 143: 18766-18776.

  4. Sarkar A and Mandal K* (2021) Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease. Angewandte Chemie, International Edition (Highlight) 60: 23492-23494.

  5. Biswas A, Raran-Kurussi S, Narayan A, Kar A, Mashurabad PC, Bhattacharyya, MK and Mandal K* (2021) Efficient refolding and functional characterization of PfAMA1(DI+DII) expressed in E. coli. Biochemistry and Biophysics Reports 26:100950. https://doi.org/10.1016/j.bbrep.2021.100950.

  6. Thakur P, Mannuthodikayil J,* Kalita G, Mandal K* and Narayanan TN,* (2021) In Situ Surface Modification of Bulk or Nano Materials by Cytochrome-c for Active Hydrogen Evolution Catalysis. Materials Chemistry Frontiers 5:1295-1300. {Featured on the cover page}

  7. Kar A, Mannuthodikayil J, Singh S, Biswas A, Dubey P, Das A and Mandal K* (2020) Efficient Chemical Protein Synthesis using Fmoc-Masked N-Terminal cysteine in Peptide Thioester Segments. Angewandte Chemie, International Edition 59:14796-14801.

  8. Kumar M, Mandal K, Blakeley MP, Wymore T, Kent SBH, Louis JM, Das A, and Kovalevsky A (2020) Visualizing Tetrahedral Oxyanion Bound in HIV‑1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design. ACSOmega 5: 11605−11617.

  9. Mannuthodikayil J*, Narayanaru S, Thakur P, Bawari S, Narayanan TN* and Mandal K* (2020) Protein denaturation induced electrocatalytic hydrogen evolution. Carbon 165:378-385.

  10. Mannuthodikayil J, Singh S, Biswas A, Kar A, Tabassum W, Vydyam P, Bhattacharyya, MK and Mandal K* (2019) Benzimidazolinone-​free peptide o-​aminoanilides for chemical protein synthesis. Organic Letters 21:9040-9044.

  11. Dang B, Shen R, Kubota, T, Mandal K, Bezanilla F, Roux B and Kent SBH* (2017) Inversion of the Side-Chain Stereochemistry of Individual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angewandte Chemie, International Edition 56:3324-3328.

  12. Dhayalan B, Mandal K, Rege N, Weiss MA, Eitel SH, Meier T, Schoenleber RO and Kent SBH* (2017) Scope and limitations of Fmoc chemistry SPPS-based approaches to the total synthesis of insulin lispro via ester insulin. Chemistry – A European Journal 23:1709-1716.

  13. Mandal K*, Dhayalan B, Avital-Shmilovici M, Tokmakoff A and Kent SBH (2016) Crystallization of enantiomerically pure proteins from quasiracemic mixtures: structure determination by X-ray diffraction of isotope-labeled ester insulin and human insulin. ChemBioChem 17:421-425.

  14. Dhayalan B, Fitzpatrick A, Mandal K, Whittaker J, Weiss MA, Tokmakoff A and Kent SBH* (2016) Efficient Total Chemical Synthesis of 13C=18O Isotopomers of Human Insulin for Isotope-Edited FTIR. ChemBioChem 17:415-420.

  15. Lee DJ§, Uppalapati M§, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riché D, Kent SBH* and Sidhu SS* (2016) A Potent D-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. ACS Chemical Biology 16:1058-1065. {Featured as ACS Editors’ Choice, February 3, 2016}

  16. Bunker R, Mandal K, Bashiri G, Chaston J, Pentelute BL, Lott JS, Kent SBH* and Baker EN* (2015) A Functional Role of Rv1738 in Mycobacterium tuberculosis Persistence Suggested by Racemic Protein Crystallography. Proceedings of the National Academy of Sciences USA 112:4310-4315. {Highlighted in Nat. Chem. Biol. (2015) 11:304}.

  17. Okamoto R, Mandal K, Sawaya MR, Kajihara Y, Yeates TO and Kent SBH* (2014) (Quasi)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis. Angewandte Chemie, International Edition 53:5194-5198.

  18. Okamoto R, Mandal K, Ling M, Luster AD, Kajihara Y and Kent SBH* (2014) Total chemical synthesis and biological activities of glycosylated and non-glycosylated forms of the chemokines CCL1 and Ser-CCL1. Angewandte Chemie, International Edition 53:5188-5193{Featured as VIP article}.

  19. Dang B, Kubota T, Mandal K and Kent SBH* (2013) Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography. Journal of the American Chemical Society, 135: 11911-11919.

  20. Smilovici MA, Mandal K, Gates ZP, Phillips NB, Weiss MA and Kent SBH* (2013) Convergent Chemical Synthesis and Xray Crystal Structure of Ester-Insulin by Racemic Protein Crystallography. Journal of the American Chemical Society 135:3173-3185.

  21. Mandal K,§ Uppalapati M,§ Ault-Riché D, Kenney J, Lowitz J, Sidhu SS* and Kent SBH* (2012) Chemical Synthesis and X-ray Structure of a Heterochiral {D-Protein Antagonist Plus Vascular Endothelial Growth Factor} Protein Complex by Racemic Crystallography. Proceedings of the National Academy of Sciences USA 109:14779-14784. {Highlighted in Chemical & Engineering News 2012, 90, 6}.

  22. Mandal K, Pentelute BL, Bang D, Gates ZP, Torbeev VY and Kent, SBH* (2012) Design, Total Chemical Synthesis, and X-ray Structure of a Protein having a Novel Linear-Loop Polypeptide Chain Topology. Angewandte Chemie, International Edition 51:1481-1486. {Featured as VIP article}

  23. Kent SBH*, Sohma Y, Liu S, Bang D, Pentelute BL and Mandal K (2012) Through the Looking Glass – a New World of Protein Enabled by Chemical Synthesis. Journal of Peptide Science 18:428-436.

  24. Mandal K and Kent SBH* (2011) Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor. Angewandte Chemie, International Edition 50:8029-8033. {Highlighted in Chemical & Engineering News 2011, 89, 27-28}

  25. Özçubukçu S, Mandal K, Wegner S, Jensen MP and He C* (2011) Selective Recognition of Americium by Peptide-Based Reagents. Inorganic Chemistry 50:7937–7939.

  26. Pentelute BL, Mandal K, Gates ZP, Sawaya MR, Yeates TO and Kent SBH* (2010) Total Chemical Synthesis and X-ray Structure of Kaliotoxin by Racemic Protein Crystallography. Chemical Communications 46:8174-8176.

  27. Banigan J, Mandal K, Sawaya MR, Thammavongsa V, Hendrickx APA, Schneewind O, Yeates TO and Kent SBH* (2010) Determination of the X-Ray Structure of the Snake Venom Protein Omwaprin by Total Chemical Synthesis and Racemic Protein Crystallography. Protein Science 19:1840-1849.

  28. Deng F–K, Mandal K, Luisier S and Kent SBH* (2010) Synthesis and comparative properties of two amide-generating resin linkers for use in solid phase peptide synthesis. Journal of Peptide Science 16:545-550.

  29. Mandal K*, Pentelute BL, Tereshko V, Thammavongsa V, Schneewind O, Kossiakoff AA and Kent SBH (2009) Racemic Crystallography of Synthetic Protein Enantiomers Used to Determine the X-ray Structure of Plectasin by Direct Methods. Protein Science 18:1146-1154. {Featured on the cover page}

  30. Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA and Kent SBH* (2009) X-ray Structure of Native Scorpion Toxin BmBKTx1 by Racemic Protein Crystallography Using Direct Methods. Journal of the American Chemical Society 131:1362-1363. {Highlighted in Chemical & Engineering News 2009, 87, 8}

  31. Torbeev VY, Raghuraman H, Mandal K, Senapati S, Perozo E and Kent SBH* (2009) Dynamics of “Flap” Structures in Three HIV-1 Protease/Inhibitor Complexes Probed by Total Chemical Synthesis and Pulse-EPR Spectroscopy. Journal of the American Chemical Society 131:884-885.

  32. Lee DJ, Mandal K, Harris PWR, Brimble MA and Kent SBH* (2009) A One-Pot Approach to Neoglycopeptides using Orthogonal Native Chemical Ligation and Click Chemistry. Organic Letters 11:5270-5273.

  33. Kotha S* and Mandal K (2009) A Retrospective on the Design and Synthesis of Novel Molecules through a Strategic Consideration of Metathesis and Suzuki–Miyaura Cross-coupling. Chemistry an Asian Journal 4:354-362.

  34. Torbeev VY, Mandal K, Terechko VA and Kent SBH* (2008) Crystal Structure of Chemically Synthesized HIV-1 Protease and a Ketomethylene Isostere Inhibitor Based on the p2/NC Cleavage Site. Bioorganic and Medicinal Chemistry Letters 18:4554-4557.

  35. Kotha S* and Mandal K (2007) Metathesis of a Novel Dienediyne System: A Unique Example Involving the Usage of in situ Generated Ethylene as Cross–Enyne Metathesis Partner. Journal of Organometallic Chemistry 692:4921-4927.

  36. Kotha S*, Shah VR and Mandal K (2007) Formation of Arenes via Diallylarenes: Strategic Utilization of Suzuki–Miyaura Cross–Coupling, Claisen Rearrangement and Ring-Closing Metathesis. Advanced Synthesis and Catalysis 349:1159-1172.

  37. Kotha S*, Mandal K, Banerjee S and Mobin SM (2007) Synthesis of Novel Quinone–Amino Acid Hybrids via Cross–Enyne Metathesis and Diels–Alder reaction as key steps. European Journal of Organic Chemistry 1244-1255.

  38. Kotha S* and Mandal K (2006) Suzuki–Miyaura Cross–Coupling and Ring–Closing Metathesis: A Strategic Combination for the Synthesis of Cyclophane Derivatives. European Journal of Organic Chemistry 5387-5393. {Cited with scheme in the book ‘Supramolecular Chemistry’ (Wiley, 2nd Ed, 2009, p344) by J. W. Steed and J. L. Atwood.}

  39. Kotha S*, Mandal K, Tiwari A and Mobin SM (2006) Diversity–Oriented Approach to Biologically Relevant Molecular Frameworks Starting with -Naphthol and Using the Claisen Rearrangement and Olefin Metathesis as Key Steps. Chemistry A European Journal 12:8024-8038.

  40. Kotha S*, Mandal K, Arora KK and Pedireddi VR (2005) New Synthetic Approach to a [1.1.6] Metapara Cyclophane Derivative via Suzuki–Miyaura Cross–Coupling and Ring-Closing Metathesis. Advanced Synthesis and Catalysis 347:1215-1218.

  41. Kotha S*, Mandal K, Deb AC and Banerjee S (2004) Microwave–Assisted Claisen Rearrangement on a silica gel Support. Tetrahedron Letters 45:9603-9605.

  42. Kotha S* and Mandal K (2004) A New Protocol for Benzoannulatiosn by Double Claisen Rearrangement and Ring–Closing Metathesis Reactions as Key Steps. Tetrahedron Letters 45:2585-2588.

  43. Kotha S* and Mandal K (2004) Metathetic Approach to Napthoxepin and Spirocyclic Molecular Frame Works. Tetrahedron Letters 45:1391-1394.

  44. Kotha S*, Banerjee, S and Mandal K (2004) Oxidative Dehydrogenation and the Aromatization of Polycycles Using o-Iodoxybenzoic Acid (IBX). Synlett 2043-2045.

    Book Chapters

  45. Total Chemical Protein Synthesis for the Determination of Novel X-Ray Structures by Racemic Protein Crystallography. Mandal K* and Kent SBH* in Present and Future Methods for Biomolecular Crystallography: The Structural Path to Defence against CBRN Agents, Read RJ, Urzhumtsev AG and Lunin VY, Eds., Springer, 2012. Pp 11 – 22.

  46. Neoglycoprotein Synthesis Using the Copper-Catalyzed Azide-Alkyne Click Resaction and Native Chemical Ligation. Wojnar J, Lee DJ, Evans CW, Mandal K, Kent SBH and Brimble MA in Click Chemistry in Glycoscience, Witczak ZJ and Bielski R, Eds., John Wiley & Sons, 2013. P 253.

    Patent Application

  47. GB1 peptidic compounds and methods for making and using the same. Sidhu SS, Uppalapati M, Ault-Riché D, Kent SBH, Mandal K, Lee DJ (2014) PCT Int. Appl. WO 2014071234 A1 20140508.

    Last updated on September 22, 2021 at 12:40 AM