1. Rajit Narayanan Cheramangalam, Tarana Anand, Priyanka Pandey, Deepa Balasubramanian, Reshmi Varghese, Neha Singhal, Sonal Nagarkar Jaiswal, Manish Jaiswal, “E2 ubiquitin conjugase Bendless is essential for PINK1-Park activity to regulate Mitofusin under mitochondrial stress,” bioRxiv 2022.10.24.513457; doi: https://doi.org/10.1101/2022.10.24.513457.

  2. Rituraj Marwaha, Simran Rawal, Purnati Khuntia, Manish Jaiswal, Tamal Das “Mechanosensitive dynamics of lysosomes regulates the emergence of leader cells during collective cell migration,” bioRxiv 2022.08.03.502740; doi: https://doi.org/10.1101/2022.08.03.502740.

  3. Nikhita Pasnuri, Manish Jaiswal, Krishanu Ray, Aprotim Mazumder “Buffered EGFR signaling regulated by spitz to argos expression ratio is critical for patterning the Drosophila eye,” bioRxiv 2021.05.19.444784; doi: https://doi.org/10.1101/2021.05.19.444784.

  4. Aishwarya S Mandya, Rajit Narayanan Cheramangalam, Manish Jaiswal, “Understanding Neurodegeneration and Neuroprotection Through Genetic Screens in Drosophila,” Insights into Human Neurodegeneration: Lessons Learnt from Drosophila, 55-88.

  5. Sayantan Datta, Manish Jaiswal, “Mitochondrial calcium at the synapse,” Mitochondrion Volume 59, July 2021, Pages 135-153.

  6. Li S, Xu C, Fu Y, Lei P, Yao Y, Zhang Y, Washburn M P, Florens L, Jaiswal M, Wu M and Mohan M., “DYRK1A interacts with Histone Acetyl Transferase p300 and CBP and localizes to enhancers,” Nucleic Acid Research(Accepted).

  7. Balakrishnan S S, Basu U, Shinde D, Thakur R, Jaiswal M and Raghu P., “Regulation of PI4P levels by PI4KIIIa during G-protein coupled PLC signaling in Drosophila photoreceptors,” J. Cell Sci. 3;131(15)

  8. Singhal N and Jaiswal M, “Pathways to Neurodegeneration: Lessons learnt from unbiased genetic screens in Drosophila,” J Genet. Jul;97(3):773-781

  9. Li-Kroeger D, Kanca O, Lee P-T, Cowan S, Lee M, Jaiswal M, Salazar J L, He Y C and Bellen, H J., “An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila,” Elife e38709

  10. Yoon WH, Sandoval H, Nagarkar-Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Shen J, Arboleda VA , Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ (2016) “Loss of Nardilysin, a mitochondrial co-chaperone for α-Ketoglutarate Dehydrogenase, promotes mTORC1 activation and neurodegeneration“. Neuron, 93:115-131.

  11. Chen K, Lin G, Haelterman NA, Ho TS, Li T, Li Z, Duraine L, Graham BH, Jaiswal M, Yamamoto S, Rasband MN, Bellen HJ (2016) “Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration“.  eLife 5:e16043.

  12. Li T, Fan J, Blanco-Sánchez B, Giagtzoglou N, Lin G, Yamamoto S, Jaiswal M, Chen K, Wei W, Lewis MT, Groves AK, Westerfield M, Jia J, Bellen HJ. (2016) “Ubr3, a novel modulator of Hh signaling affects the degradation of Costal-2 and Kif7 through poly-ubiquitination“. PLoS Genetics, 12:e1006054.

  13. Fang X, Zhou J, Liu W, Duan X, Gala U, Sandoval H, Jaiswal M, Tong C. (2016) “Dynamin Regulates Autophagy by Modulating Lysosomal Function“. J Genet Genomics20;43(2):77-86.

  14. David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine L, Zuo Z, Zhang S, Bellen HJ. (2016) “WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes“. Developmental Cell 36:139-151.

    • Previewed in Developmental Cell, 36, 129–130, by Jacques Montagne: A Wacky Bridge to mTORC1 Dimerization

  15. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper T, Graham BH and Bellen HJ. (2015) “Impaired mitochondrial energy production causes light induced photoreceptor degeneration independent of oxidative stress“. PLoS Biology 13(7): e100219.

    • This work uncovered a novel mechanism of retinal degeneration due to mitochondrial impairments. A better understanding of the multiple ways in which mitochondrial disorders can trigger blindness will help design new treatments.

    • Featured cover page image article.

    • Featured at National Eye Health Week, MRC Clinical Sciences Centre UK,
      http://bpod.mrc.ac.uk/archive/2015/9/23 Losing Sight.

  16. Tian X*, Gala U*, Zhang Y, Yang H, Shang W, Nagarkar-Jaiswal S, Sillitoe R, Jaiswal M, di Ronza A, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Venkatachalam K, Fan H, Bellen HJ, Tong C. (2015) “A Voltage gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis“. PLoS Biology 13(3):e1002103. (*equal contribution)

    • Recommended in F1000Prime as an exceptional article, F1000Prime.com/ 725404926#eval793505890

    • Featured in Eurekalert/AAAS: Nerve cells borrow a trick from their synapses to dispose of garbage. 26 March 2015 (http://www.eurekalert.org/pub_releases/2015-03/p-ncb032315.php)

  17. Liu L, Zhang K, Sandoval H, Yamamoto S, Jaiswal M, Sanz E, Li Z, Graham BH, Quintana A and Bellen HJ. (2015) Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell 160:177-190.

    • Featured in Science daily: Novel precursor to neurodegeneration identified. 15 January 2015. www.sciencedaily.com/releases/2015/01/150115134719.htm.

  18. Yamamoto S*, Jaiswal M*, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LE, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler WF, Bellen HJ. (2014) “A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases“. Cell 159:200-214. (*equal contribution)

    • This paper describes the identification of 165 fly genes required for neuronal development, function and maintenance. This information was used for prioritization and validation of human disease associated genes that includes ANKLE2 discovery.

    • Recommended in F1000Prime as an exceptional article, F1000Prime.com/718889692

    • Featured in Nature Methods 2014 11(12):1197 by Todorovic V: “Flies give wings to human disease studies”.

  19. Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL, Zhang K, Bei D, Xiong B, Charng WL, Busby T, Jawaid A, David G, Jaiswal M, Venken K, Yamamoto S, Chen R and Bellen HJ. (2014) “Large-scale identification of chemically induced mutations in Drosophila melanogaster“. Genome Research 24(10):1707-18.

    • This paper provides key information for designing mapping experiment using whole genome sequencing.

  20. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. (2014) “The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration“. PLoS Biology 12:e1001847.

  21. Haelterman NA, Yoon WH, Sandoval H, Jaiswal M, Shulman JM, Bellen HJ. (2014) “A mitocentric view of Parkinson’s Disease“. Annual Review of Neuroscience 37:137-159

  22. Charng WL, Yamamoto S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Gibbs S, Lu HC, Chen K, Giagtzoglou N, Bellen HJ. (2014) “Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates Notch signaling via Rab1 and Rab11“. PLoS Biology 12:e1001777.

    • Featured in PLoS Biology 12(1): e1001778 by Sedwick C : Deep-Fried Signaling: tempura Gets Notch Cooking.

  23. Sandoval H, Yao C, Chen K, Jaiswal M, Donti T, Lin Y, Bayat V, Xiong B, Zhang K, David G, Charng W, Yamamoto S, Duraine L, Graham BH and Bellen HJ. (2014) “Drosophila Mitofusin combined roles in mitochondrial and cholesterol trafficking regulates synaptic function and growth“. eLife 3:e03558.

  24. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, Charng W-L, David G, Haueter C, Yamamoto S, Graham BH, Bellen HJ.  (2013) “The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit“. Journal of Cell Biology 200:807-820.

  25. Bayat V*, Thiffault I*, Jaiswal M, Tétreault M, Donti T, Sasarman F, Bernard G, Demers-LaMare J, Dicaire MJ, Mathieu J, Vanasse M, Bouchard JP, Rioux MF, Lourenco CM, Li Z, Haueter C, Shoubridge EA, Graham BH, Brais B, Bellen HJ. (2012) “Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans“. PLoS Biology 10:e1001288. (*equal contribution)

    • Featured in ScienceDaily: Collaboration rapidly connects fly gene discovery to human disease. 20 March 2012. www.sciencedaily.com/ releases/2012/03/ 120320195802.htm.

  26. Yamamoto S, Charng W-L, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ. (2012) “A mutation in EGF repeat 8 of Notch discriminates between Serrate/Jagged and Delta family ligands“. Science 338:1229-1232.

    • Recommended in F1000Prime as an exceptional article, F1000Prime.com/717967100

  27. Xiong B, Bayat V, Jaiswal M, Zhang K, Sandoval H, Charng W-L, Li TC, David G, Duraine L, Lin YQ, Neely GG, Yamamoto S, Bellen HJ. (2012) “Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells“. PLoS Biology 10:e1001438.

  28. Jaiswal M*, Sandoval H*, Zhang K, Bayat V, Bellen HJ. (2012) “Probing mechanisms that underlie human neurodegenerative disease in Drosophila“. Annual Review of Genetics 46:371-396. (* equal contribution)

  29. Bayat V, Jaiswal M, Bellen HJ. (2011) “The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases“. Current Opinion in Neurobiology 21:182-188.

  30. Jaiswal M, Agrawal N and Sinha P. (2006) “Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila“. Development 133(5): 925-935.