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We are interested in understanding the origin and outcome of T cell receptor (TCR) induced ion flux in T cell development and effector function. Point mutations in molecular components involved in calcium and magnesium flux have been associated with severe immunodeficiency in human and mice. Using a combination of molecular, genetic, biochemical and imaging approaches, we are studying the intracellular signaling networks regulated by ion flux and their role in regulating the
physiological and pathological processes such as inflammation and cancer.<\/p>\n
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We are interested in understanding the origin and outcome of T cell receptor (TCR) induced ion flux in T cell development and effector function. Point mutations in molecular components involved in calcium and magnesium flux have been associated with severe immunodeficiency in human and mice. Using a combination of molecular, genetic, biochemical and imaging approaches, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9"}],"version-history":[{"count":5,"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":59,"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions\/59"}],"wp:attachment":[{"href":"https:\/\/www.tifrh.res.in\/~mvig\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}