{"id":53,"date":"2019-02-19T07:00:55","date_gmt":"2019-02-19T01:30:55","guid":{"rendered":"http:\/\/ftp.tifrh.res.in:8081\/~anusheela\/newsletter\/?p=53"},"modified":"2020-07-17T13:50:48","modified_gmt":"2020-07-17T08:20:48","slug":"tracing-infantile-cataracts","status":"publish","type":"post","link":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/2019\/02\/19\/tracing-infantile-cataracts\/","title":{"rendered":"Tracing Infantile Cataracts"},"content":{"rendered":"\n<p><em>Khandekar Jishan Bari and K.V.R Chary<\/em><\/p>\n\n\n\n<p>Infantile cataracts are a root cause of blindness in children. When a cataract develops in the eye, the lens slowly becomes opaque. A mutant form of Gamma S-crystallin, a protein abundant in the eye lens cortex, is associated with this form of cataract. A study, led by Prof.K.V.R. Chary, tried to uncover whether this opacity was caused due to any structural and functional changes in the mutant form of Gamma S-crystallin. With the help of sophisticated spectroscopic experiments, it was found that the mutant protein was structurally unstable as compared to the healthy protein, and this structural weakness is caused by a change in the 67th amino acid of this protein.<br><br><a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2018.10.187\">https:\/\/doi.org\/10.1016\/j.bbrc.2018.10.187<\/a><br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Khandekar Jishan Bari and K.V.R Chary Infantile cataracts are a root cause of blindness in children. When a cataract develops in the eye, the lens slowly becomes opaque. A mutant form of Gamma S-crystallin, a protein abundant in the eye lens cortex, is associated with this form of cataract. A study, led by Prof.K.V.R. Chary, &hellip; <a href=\"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/2019\/02\/19\/tracing-infantile-cataracts\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Tracing Infantile Cataracts&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":54,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11,10],"class_list":["post-53","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infocus","tag-biology","tag-nmr"],"_links":{"self":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/53"}],"collection":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/comments?post=53"}],"version-history":[{"count":11,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/53\/revisions"}],"predecessor-version":[{"id":694,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/53\/revisions\/694"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/media\/54"}],"wp:attachment":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/media?parent=53"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/categories?post=53"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/tags?post=53"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}