{"id":57,"date":"2019-02-19T06:50:55","date_gmt":"2019-02-19T01:20:55","guid":{"rendered":"http:\/\/ftp.tifrh.res.in:8081\/~anusheela\/newsletter\/?p=57"},"modified":"2020-07-16T15:44:45","modified_gmt":"2020-07-16T10:14:45","slug":"signals-in-fly-development","status":"publish","type":"post","link":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/2019\/02\/19\/signals-in-fly-development\/","title":{"rendered":"Signals in Fly Development"},"content":{"rendered":"\n<p><em>Nikhita Pasnuri and Aprotim Mazumder<\/em><br><\/p>\n\n\n\n<p>Cells communicate using convoluted chemical signals. Given the limited number of proteins, how does a cell assess the input message and act accordingly? One plausible approach could be by applying different strengths of the same input. Using <em>Drosophila melanogaster<\/em>, the fruit-fly, as a model system, a method was adapted and modified: single-molecule mRNA fluorescence in-situ hybridization (smFISH) for whole-mount tissues. smFISH quantitatively gauged transcription of the target genes, and was used as a proxy to determine the input signal strength. In the lab, smFISH is being applied to understand how different signal strengths can bring about differences during the development of the fly.<br><br><a href=\"https:\/\/doi.org\/10.1016\/j.mod.2018.08.006\">https:\/\/doi.org\/10.1016\/j.mod.2018.08.006<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"2048\" height=\"1564\" src=\"http:\/\/ftp.tifrh.res.in:8081\/~anusheela\/newsletter\/wp-content\/uploads\/2019\/02\/nikhita.jpg\" alt=\"\" class=\"wp-image-58\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Nikhita Pasnuri and Aprotim Mazumder Cells communicate using convoluted chemical signals. Given the limited number of proteins, how does a cell assess the input message and act accordingly? One plausible approach could be by applying different strengths of the same input. Using Drosophila melanogaster, the fruit-fly, as a model system, a method was adapted and &hellip; <a href=\"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/2019\/02\/19\/signals-in-fly-development\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Signals in Fly Development&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":58,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11,12],"class_list":["post-57","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infocus","tag-biology","tag-fly"],"_links":{"self":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/57"}],"collection":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/comments?post=57"}],"version-history":[{"count":12,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/57\/revisions"}],"predecessor-version":[{"id":227,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/57\/revisions\/227"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/media\/58"}],"wp:attachment":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/media?parent=57"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/categories?post=57"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/tags?post=57"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}