{"id":70,"date":"2019-02-19T06:35:41","date_gmt":"2019-02-19T01:05:41","guid":{"rendered":"http:\/\/ftp.tifrh.res.in:8081\/~anusheela\/newsletter\/?p=70"},"modified":"2020-07-16T15:45:12","modified_gmt":"2020-07-16T10:15:12","slug":"ligand-binding-mechanisms","status":"publish","type":"post","link":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/2019\/02\/19\/ligand-binding-mechanisms\/","title":{"rendered":"Ligand-Binding Mechanisms"},"content":{"rendered":"\n<p><em>Navjeet Ahalawat, Jagannath Mondal , and\u00a0 Pramodh Vallurupalli<\/em><br><\/p>\n\n\n\n<p>The process of Ligand-binding to solvent inaccessible cavities in receptor proteins has been rather elusive. A study, led by Dr. Jagannath Mondal and Dr. Pramodh Vallurupalli, tried to gain mechanistic insight into the different pathways by which benzene, a ligand, can find its way into a deep-seated cavity in the mutant form of the T4 Lysozyme, a protein receptor, at an atomistic level.<br><br><a href=\"https:\/\/doi.org\/10.1371\/journal.pcbi.1006180\">https:\/\/doi.org\/10.1371\/journal.pcbi.1006180<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"403\" height=\"445\" src=\"http:\/\/ftp.tifrh.res.in:8081\/~anusheela\/newsletter\/wp-content\/uploads\/2019\/02\/navjeet.png\" alt=\"\" class=\"wp-image-74\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Navjeet Ahalawat, Jagannath Mondal , and\u00a0 Pramodh Vallurupalli The process of Ligand-binding to solvent inaccessible cavities in receptor proteins has been rather elusive. A study, led by Dr. Jagannath Mondal and Dr. Pramodh Vallurupalli, tried to gain mechanistic insight into the different pathways by which benzene, a ligand, can find its way into a deep-seated &hellip; <a href=\"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/2019\/02\/19\/ligand-binding-mechanisms\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Ligand-Binding Mechanisms&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":74,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[14,10,13],"class_list":["post-70","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infocus","tag-molecular-dynamics","tag-nmr","tag-protein"],"_links":{"self":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/70"}],"collection":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/comments?post=70"}],"version-history":[{"count":8,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/70\/revisions"}],"predecessor-version":[{"id":263,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/posts\/70\/revisions\/263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/media\/74"}],"wp:attachment":[{"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/media?parent=70"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/categories?post=70"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~newsletter\/index.php\/wp-json\/wp\/v2\/tags?post=70"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}