{"id":1165,"date":"2022-04-19T18:02:55","date_gmt":"2022-04-19T18:02:55","guid":{"rendered":"https:\/\/ftp.tifrh.res.in\/~sciencemedia\/?p=1165"},"modified":"2023-09-05T08:10:00","modified_gmt":"2023-09-05T08:10:00","slug":"what-does-glass-and-a-dense-layer-of-cells-have-in-common","status":"publish","type":"post","link":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/2022\/04\/19\/what-does-glass-and-a-dense-layer-of-cells-have-in-common\/","title":{"rendered":"What does glass and a dense layer of cells have in common?"},"content":{"rendered":"\n<p>Window glass and a dense layer of cells? They are more alike than they appear. This video series shows how Souvik Sadhukhan (graduate student at <a rel=\"noreferrer noopener\" href=\"https:\/\/www.tifrh.res.in\/\" target=\"_blank\">TIFR Hyderabad<\/a>) came up with a theoretical explanation of the similarities between the two! Outreach effort funded by <a rel=\"noreferrer noopener\" href=\"https:\/\/indiabioscience.org\/projects\/indiabioscience-outreach-grant-iog\" target=\"_blank\">IndiaBioscience Outreach Grant<\/a>. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/ftp.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FQr0QN8UcAIlxyS.jpg\" alt=\"\" class=\"wp-image-1166\"\/><\/figure>\n\n\n\n<p>When hot liquid glass is rapidly cooled to a solid form, the molecules get arranged randomly. While the glass may look like a solid to the bare eye, the random arrangement of glass molecules convey a different picture altogether. More on this puzzle:<\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Stories from the life sciences: What does glass and a dense layer of cells have in common? (PART I)\" width=\"774\" height=\"435\" src=\"https:\/\/www.youtube.com\/embed\/y2QwEW5uA0w?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>This segment goes into some details of the scientific approach. It navigates through the stages involved in building the theoretical framework. Here&#8217;s the second part of the story&#8230;straight from the lab bench, oops! sorry..desktop.<\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Stories from the life sciences: What does glass and a dense layer of cells have in common? (PART II)\" width=\"774\" height=\"435\" src=\"https:\/\/www.youtube.com\/embed\/Ta4HJGA_nNo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Earlier studies which have modelled the movement of a monolayer of confluent cells report that properties such as cell shape and movement are instrumental in determining glass-like behaviour in cells.<\/p>\n\n\n\n<p>Only the cells which have regular boundaries (Figure 1) and are less motile are considered to be in glass-like state. However, in his simulations, Souvik observed that even irregular-shaped cells (Figure 2) with low motility can show dynamics similar to glass molecules.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"680\" height=\"249\" src=\"https:\/\/ftp.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRa-b3MaMAAJgIS.jpg\" alt=\"\" class=\"wp-image-1167\" srcset=\"https:\/\/www.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRa-b3MaMAAJgIS.jpg 680w, https:\/\/www.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRa-b3MaMAAJgIS-300x110.jpg 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/figure>\n\n\n\n<p>Souvik had been working with a population of cells that were created virtually by a computer programme. Do these virtual cells have any properties in common with their real world counterparts?<\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Stories from the life sciences: What does glass and a dense layer of cells have in common?(PART III)\" width=\"774\" height=\"435\" src=\"https:\/\/www.youtube.com\/embed\/WLxBErzv6sI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>This study has been published in Physical Review E. <a href=\"https:\/\/journals.aps.org\/pre\/abstract\/10.1103\/PhysRevE.103.062403\" data-type=\"URL\" data-id=\"https:\/\/journals.aps.org\/pre\/abstract\/10.1103\/PhysRevE.103.062403\" target=\"_blank\" rel=\"noreferrer noopener\">Theory and simulation for equilibrium glassy dynamics in cellular Potts model of confluent biological tissue, Souvik Sadhukhan and Saroj Kumar Nandi Phys. Rev. E 103, 062403<\/a>.<\/p>\n\n\n\n<p>We reached out to artists for creating illustrations that would help explain the scientific concepts in a lucid way. Rutuja Chalke created the engaging illustrations and motion graphics for this video series. <a rel=\"noreferrer noopener\" href=\"https:\/\/twitter.com\/ipsawonders\" data-type=\"URL\" data-id=\"https:\/\/twitter.com\/ipsawonders\" target=\"_blank\">Ipsa Jain<\/a> designed the beautiful poster.<\/p>\n\n\n\n<p>In the first video, Souvik said,\u201cInitially, I had some hesitation about working on biological application based problems because I belong to a core physics background.\u201d Update: He has been recently spotted in Manish Jaiswals lab learning to dissect flies!<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"961\" height=\"916\" src=\"https:\/\/ftp.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRbQ6ykaQAArfUG.jpg\" alt=\"\" class=\"wp-image-1168\" srcset=\"https:\/\/www.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRbQ6ykaQAArfUG.jpg 961w, https:\/\/www.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRbQ6ykaQAArfUG-300x286.jpg 300w, https:\/\/www.tifrh.res.in\/~sciencemedia\/wp-content\/uploads\/2023\/09\/FRbQ6ykaQAArfUG-768x732.jpg 768w\" sizes=\"(max-width: 961px) 100vw, 961px\" \/><\/figure>\n\n\n\n<p class=\"has-small-font-size\"><br><em>Credits:<br><br>Direction and videography: Anusheela Chatterjee<br>Script: Anusheela Chatterjee (with inputs from Souvik Sadhukhan and reviewed by Saroj K. Nandi)<br>Illustrations and motion graphics: Rutuja D. Chalke<br>Simulations: Souvik Sadhukhan<br>Title video: Basil Thurakkal<\/em><\/p>\n\n\n\n<p class=\"has-small-font-size\"><em><br>Acknowledgements:<br>\u2013 Antik Bhattacharya&nbsp;<br>\u2013 M.R Jishnu Seshadri, Anugraha A., Basil Thurakkal (initial videography attempts)<\/em><br><em>\u2013 Anugraha A. (syncing of initially recorded files)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Window glass and a dense layer of cells? They are more alike than they appear. This video series shows how Souvik Sadhukhan (graduate student at&hellip;<\/p>\n","protected":false},"author":2,"featured_media":1169,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/posts\/1165"}],"collection":[{"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/comments?post=1165"}],"version-history":[{"count":5,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/posts\/1165\/revisions"}],"predecessor-version":[{"id":1174,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/posts\/1165\/revisions\/1174"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/media\/1169"}],"wp:attachment":[{"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/media?parent=1165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/categories?post=1165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tifrh.res.in\/~sciencemedia\/index.php\/wp-json\/wp\/v2\/tags?post=1165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}