“Our laboratory is located at the Tata Institute of Fundamental Research in Hyderabad, India (17°26´ N, 78°18´ E). Our research interests lie at the interface of chemistry and biology. We use synthetic organic chemistry, total chemical protein synthesis and protein crystallography to understand and then precisely control the molecular basis of protein function”

Pre-thesis seminars: DONE!

Huge congratulations to our trio of scholars—Akash, Vishal, and Arighna—on successfully presenting their pre-thesis seminars! We’re so proud of your hard work and dedication. Onward to the final defense!

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Engineered Cyclic Peptide Targeting Malaria

Check out our recent work on fighting malaria with engineered cyclic peptide which shows 20-fold stronger binding to malaria target Pf-AMA1 and blocks parasite invasion

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Recent Talk at NOST

Delivered a talk at #NOSTOCC2025 on “Exploring Reciprocal Chiral Specificity to Inhibit Red Blood Cell Invasion by Malaria Parasites.” A step forward in the fight against malaria with precision molecular design.

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Dynamic Binding of PfAMA1 and PfRON2

Unraveling dynamic protein-protein interactions critical for malaria parasite invasion: Our study deciphers how the flexible DII loop of PfAMA1 engages PfRON2, opening new avenues for anti-malarial drug discovery.

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Best Poster Presentation Award

Congratulations to Arighna Sarkar on receiving the best poster award at the 10th International Peptide Symposium organized by the Indian Peptide Society

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Best Poster Presentation Award

Congratulations to Mrinmoy Jana on receiving the best poster award in biochemistry at the ‘Current Trends in Drug Discovery and Advances in Diagnostics: Chemical Biology approaches’, 11th Annual Meeting of Chemical Biology Society-India, held at Adichunchanagiri University, Karnataka.

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Kalyaneswar Mandal, Ph.D.

Tata Institute of Fundamental Research Hyderabad, India

kmandal@tifrh.res.in