The Laboratory of T Cell Ion Flux and Signaling

We are interested in understanding the origin and outcome of T cell receptor (TCR) induced calcium flux in T cell development and effector function. Point mutations in molecular components involved in calcium flux have been associated with severe immunodeficiency in human and mice. Using a combination of molecular, genetic, biochemical and imaging approaches, we are studying the molecular basis of intracellular calcium signaling via CRAC channels and its role in the regulation of physiological and pathological processes such as inflammation and cancer.