Associate Professor (G)
  kanchan @ tifrh . res . in
  FReTB, PI-204
Personal Webpage

Research Overview

Research in our lab is focused on self-assembled protein aggregates called amyloids, which play critical roles in diseases such as Alzheimer’s and Parkinson’s diseases, and in bacterial biofilm formation. We use several biophysical techniques to characterize the self-assembly or disassembly of amyloid species. Single-molecule fluorescence techniques are also used to determine the influence of proteins such as chaperones and apolipoprotein E on amyloid aggregation in vivo. Lastly, we also develop tools such as fluorescence correlation spectroscopy and single-molecule FRET (smFRET) for quantitative characterization of the early events of protein aggregation.