3078
manish @ tifrh . res . in
FReTB, PI-206
Personal Webpage
Research Overview
Our lab seeks to decipher intercellular and inter-organelle communication that orchestrates metabolic homeostasis. We combine unbiased genetic screens, genomics, molecular biology, biochemistry, and imaging tools to address our research questions. Our current research is focused on identifying signalling networks that reposition mitochondrial dynamics and mitochondrial biogenesis to adapt to physiological, developmental, or pathogenic conditions. Since the majority of genes and pathways are conserved between flies and humans, and the fly model provides an unparalleled advantage of genetic manipulation, we are also interested in identifying disease-linked mutations and associated pathogenic mechanisms using the “Human-Drosophila-Pipeline” in collaboration with clinical geneticists. Areas of our interest are rare neurological/neurodegenerative and mitochondrial diseases.