mrinals @ tifrh . res . in
  H-2, PI-102
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Research Overview

Our lab is interested in understanding chromosomal replication and genome maintenance. We address various aspects of DNA replication such as the regulatory mechanisms governing the selection of error-prone polymerases during replication and the organization of the replisome complex in various genomic contexts. We also explore the role of the mammalian replication system in the context of the pathophysiology of the autosomal recessive disorder Meier-Gorlin syndrome, which is associated with mutations in the pre-replication complex. Our lab is also keen on understanding the cellular mechanisms underlying the repair of DNA–protein crosslinks.