3113
sholla @ tifrh . res . in
FReTB, PI-109
Personal Webpage
Research Overview
A fundamental aspect of eukaryotic genomes is their ability to organize chromatin both functionally and spatially within the nucleus. While it is known that genome organization and regulation depend on a coordinated interplay of several mechanisms and features—including chromosome folding, compartmentalization, nuclear peripheral tethering, and underlying epigenetic marks—a comprehensive understanding of the factors and mechanisms that regulate the structure and function of the 3D genome, especially during development and in disease, remains both ideal and essential. Broadly, our lab aims to understand the biological significance of 3D genome organization in development and disease states by taking an interdisciplinary approach—combining genomics, proteomics, and advanced imaging. Initially, we will leverage the powerful genetics of S. pombe (fission yeast) to uncover novel regulators and mechanisms of 3D genome organization, and subsequently test their functions in higher eukaryotes.